Ranitidine pharmacokinetics in newborn infants.

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Ranitidine pharmacokinetics in newborn infants.

Few data are available for ranitidine pharmacokinetics in the first few days of life. Twenty seven newborn infants were treated with intravenous ranitidine because they were vomiting blood, although they had a negative Apt's test. Each infant provided two blood samples at randomly selected times 30-360 minutes after a 2.4 mg/kg intravenous bolus of ranitidine. A single exponential equation for ...

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The pharmacokinetics of cefotaxime were determined in newborn infants who were 1 to 7 days of age. Mean peak serum concentrations of 116 and 132 micrograms/ml were observed at completion of a 10-min intravenous infusion of 50 mg of cefotaxime per kg in low and average birth weight infants, respectively. The mean elimination half-lives were 4.6 and 3.4 h and rates of clearance from serum were 23...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 1993

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.68.5_spec_no.602